아래 논문은 자연상태의 불소가 함유된 지하수와 불화나트륨에 노출 된 수컷쉬의 생식능력에 관한 실험입니다.

Biol Trace Elem Res. 2019 Dec 13. doi: 10.1007/s12011-019-01994-y. [Epub ahead of print]

A Comparative Analysis of Fluoride-Contaminated Groundwater and Sodium Fluoride-Induced Reproductive Toxicity and Its Reversibility in Male Rats.

불소에 오염된 지하수와 불화나트륨이 수컷 쥐의 생식기능에 미치는 독성과 회복에 관한 비교분석

Chaithra B¹, Sarjan HN¹, Shivabasavaiah².

Abstract

The present study was undertaken to investigate the toxic effect of sodium fluoride (NaF)- and fluoride (F)-contaminated groundwater on male reproduction and it's reversibility in male rats. Adult male rats were orally treated with different concentrations of NaF- (1 mg, 5 mg, and 10 mg/kg/bw/rat) and F-contaminated groundwater for 52 days and after the confirmation of F-induced damage, the rats were allowed for recovery studies for 52 days. Exposure of NaF- and F-contaminated groundwater caused significant decline in total sperm count, sperm motility, serum concentration of testosterone, activities of testicular 3β-HSDH, counts of type A spermatogonia, preleptotene spermatocytes, midpachytene spermatocytes, elongated spermatids and round spermatids, activities of testicular and spermatozoa SOD and CAT, and increase in sperm abnormality and concentration of MDA of testis and spermatozoa compared to controls. Further, significant histological alterations characterized by shrunken seminiferous tubules and degeneration of different stages of spermatogonial cells were observed in rats treated with NaF of 10 mg/kg/bw and F-contaminated groundwater Majority of parameter studied showed severe damage in 10 mg/kg/bw of NaF-treated rats compared to that of F-contaminated groundwater. Further, dose-dependent alterations were observed with increase in concentration of NaF in most of the parameters. In recovery group rats of NaF- and F-contaminated groundwater, all the parameters were restored to control levels. The present study revealed the toxic effect of NaF and F-contaminated groundwater on male reproductive system of rats and the effects induced by NaF were dose-dependent. In addition, the study clearly revealed that F-induced toxicity on male reproduction is reversible in short-term exposure.

불소에 오염 된 치하수와 불화나트륨에 기인한 수컷 쥐의 생식능력은 복용량에 따라 다르다. 또한 불소이온의 수컷 쥐의 생식능력에 미치는 독성은 단기적인 노출에서는 가역적이다.