불소는 갑상선기능저하증의 원인이 될 수 있다? YES, 과도한 불소섭취와 갑상선기능저하증은 관련이 깊습니다.

Indian J Dent Res. 2018 May-Jun;29(3):358-363. doi: 10.4103/ijdr.IJDR_505_16.

A systematic analysis on possibility of water fluoridation causing hypothyroidism.

Chaitanya NCSK¹, Karunakar P², Allam NSJ¹, Priya MH¹, Alekhya B¹, Nauseen S¹.

Author information

1

Department of Oral Medicine and Radiology, Principal, Panineeya Institute of Dental Sciences, Hyderabad, Telangana, India.

2

Department of Conservative Dentistry and Endodontics, Panineeya Institute of Dental Sciences, Hyderabad, Telangana, India.

Abstract

Background:

Community water fluoridation is widely used worldwide and its role in preventive dental health care is well established. However, there is sufficient evidence of the ill effects of excessive fluoride content in water, causing skeletal and dental fluorosis. Alongside, there was also extraskeletal and dental manifestations of excessive fluorides reported. They include the effect on thyroid function, but the literature regarding this is sparse.

Aim:

The present systematic review aims to analyze the data from controlled studies about the effect of fluoride on thyroid function.

Materials and Methods:

A systematic literature search was performed using PUBMED, MEDLINE, EMBASE, COCHRANE Library, EBSCO search, and the internet search, with language restriction to English. The search included published studies which dealt with the association of fluorine with hypothyroidism, from January 1981 to November 2015. Literature search was done using keywords: fluoride and hypothyroidism, dental fluorosis and thyroid disorders, systemic fluorosis and thyroid disease, excessive water fluoridation and hypothyroidism, thyroid and fluoride, fluorosis and its adverse effects.

Results:

Out of 166 publications, related to search strategy, 37 full articles which were related with the association of fluoride and hypothyroidism were acquired for further inspection. Out of the 37 articles, 10 articles met the inclusion criteria. The data were extracted and placed in an excel sheet and were analyzed. The analysis suggested a positive correlation of excess fluoride and hypothyroidism.

Conclusion:

The present systematic review suggests a positive correlation between excess fluoride and hypothyroidism. This calls the need for further well-controlled studies in this otherwise emerging alarming issue. It also calls for considerable community network through health informatics for problem sensitization.

현재의 체계적 논문분석에 결과는 과도한 불소와 갑상선기능저하증과의 상당한 상관관계가 있음을 시사한다.

KEYWORDS:

Hypothyroidism; systematic analysis; water fluoridation