| subject | 하이드록시아파타이트와 불소 겔의 초기충치 재광화효과 비교 연구 |
|---|---|
| writer | 관리자 |
| date | 20-09-21 12:29 |
| hit | 900 |
관련링크본문
2020 Jul 22;6:9.
doi: 10.1038/s41405-020-0037-5. eCollection 2020.
Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study
Bennett T Amaechi 1 , Parveez Ahamed AbdulAzees 1 , Linda O Okoye 2 , Frederic Meyer 3 , Joachim Enax 3
Abstract
Objective: The present in vitro study investigated if simulated daily use of hydroxyapatite-based gel (15% HAP) remineralizes early caries lesions as effective as weekly use of high fluoride (12,500 ppm) concentration gel, comparing them with artificial saliva alone.
Materials and methods: Three tooth blocks were produced from each of 20 bovine teeth. Caries-like lesion was created on each block by 4-day demineralization in acidified gel. The blocks were randomized into three remineralization groups (20 blocks/group); Hydroxyapatite-based gel (Karex gelée, 15% HAP, fluoride-free), fluoride-based gel (Elmex gelée, 12,500 ppm F-), and artificial saliva (AS). Remineralization was conducted using pH-cycling model for 28 days with storage in AS. The pH cycling model consisted of 2 h demineralization once daily for all groups, and 3 min HAP gel application once daily, 3 min fluoride gel application once weekly, or remain in AS only respectively. Baseline and post-test mineral loss were quantified using microradiography.
Results: Paired t-tests (baseline vs. post-Test) indicated significant (p < 0.0001) remineralization in all groups. When compared against each other using Games-Howell's multiple comparison test, no significant difference in remineralization was observed between the two gels, but both gels exhibited significantly (p < 0.001) higher percentage mineral gain (HAP:39 ± 7%; fluoride:41 ± 11%) than AS alone (6 ± 2%).
Conclusion: Hydroxyapatite-based gel (15% HAP) was as effective as fluoride-based gel (12,500 ppm F-) in remineralizing initial caries lesion. 15% 하이드록시아파타이트 기반 겔은 불소 12,500ppm의 초기충치 재광화력 만큼 효과적이다.
Keywords: Minimal intervention dentistry; Oral hygiene. https://pubmed.ncbi.nlm.nih.gov/32714565/
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https://pubmed.ncbi.nlm.nih.gov/32714565/
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