아래의 저널은 불화나트륨이 면역체계에 미칠 수 있는 영향에 관한 최신 연구입니다.

Environ Pollut. 2019 Nov 15:113583. doi: 10.1016/j.envpol.2019.113583. [Epub ahead of print]

Sodium fluoride exposure triggered the formation of neutrophil extracellular traps.

Wang JJ¹, Wei ZK², Han Z³, Liu ZY³, Zhang Y³, Zhu XY², Li XW², Wang K², Yang ZT⁴.

Abstract

In recent years, numerous studies paid more attention to the molecular mechanisms associated with fluoride toxicity.

최근 들어, 많은 연구들이 불소독성과 연관 된 분자역학에 주목하고 있다.

However, the detailed mechanisms of fluoride immunotoxicity in bovine neutrophils remain unclear. Neutrophil extracellular traps (NETs) is a novel immune mechanism of neutrophils. We hypothesized that sodium fluoride (NaF) can trigger NETs activation and release, and investigate the related molecular mechanisms during the process. We exposed peripheral blood neutrophils to 1 mM NaF for 120 min in bovine neutrophils. The results showed that NaF exposure triggered NET-like structures decorated with histones and granule proteins. Quantitative measurement of NETs content correlated positively with the concentration of NaF. Mechanistically, NaF exposure increased reactive oxygen species (ROS) levels and phosphorylation levels of ERK, p38, whereas inhibiting the activities of superoxide dismutase (SOD) and catalase (CAT) compared with control neutrophils. NETs formation is induced by NaF and this effect was inhibited by the inhibitors diphenyleneiodonium chloride (DPI), U0126 and SB202190. Our findings described the potential importance of NaF-triggered NETs related molecules, which might help to extend the current understanding of NaF immunotoxicity.

우리 연구는 불화나트륨이 유발할 수 있는 호중구세포밖덫(NETs)이 분자들과 관련이 있다는 것이고 이는 불화나트륨의 면역독성을 이해하는데 도움이 될 수 있다.