J Nanobiotechnology. 2019 Jan 25;17(1):17. doi: 10.1186/s12951-019-0454-6.

Enamel remineralization and repair results of Biomimetic Hydroxyapatite toothpaste on deciduous teeth: an effective option to fluoride toothpaste.

생체모방 하이드록시아파타이트 페이스트의 에나멜 재광화와 리페어 결과 : 불소치약에 대한 효과적인 옵션

Bossù M¹, Saccucci M², Salucci A¹, Di Giorgio G¹, Bruni E³, Uccelletti D³, Sarto MS⁴, Familiari G⁵, Relucenti M⁵, Polimeni A¹.

Author information

Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161, Rome, Italy.

Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161, Rome, Italy. matteo.saccucci@uniroma1.it.

Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

4

Department of Aerospace, Electrical and Energy Engineering, Sapienza University of Rome, Via Eudossiana 18, 00184, Rome, Italy.

5

Department of Human Anatomy, Histology, Forensic Medicine and Orthopaedics Section of Human Anatomy Electron Microscopy Unit, Laboratory "Pietro M. Motta" Faculty of Pharmacy and Medicine, University of Rome La Sapienza, Via A. Borelli 50, 00161, Rome, Italy.

Abstract

BACKGROUND:

Dental caries is a recognized worldwide public health problem. Despite being one of the most effective strategies against dental caries, the excessive use of fluorine may result in a potential risk of developing dental fluorosis especially in children under age of six. The purpose of this work is to analyze a fluorine-free toothpaste containing Biomimetic Hydroxyapatite to assess enamel re-mineralizing and repairing properties.

RESULTS:

The study was performed in vitro and in vivo, comparing the hydroxyapatite toothpaste with two others toothpaste containing different fluorine concentrations. The coating effect of the micro-structured Hydroxyapatite nanoparticles reintegrates the enamel with a biomimetic film reproducing the structure and the morphology of the biologic Hydroxyapatite of the enamel. As demonstrated, the coating is due to the deposit of a new layer of apatite, which presents fewer particles than the natural enamel, not based on the chemical-physical changes occurring in fluorinated toothpastes. Moreover, it shows resistance to brushing as a consequence of chemical bonds between the synthetic and natural crystals of the enamel.

CONCLUSIONS:

The use of Biomimetic Hydroxyapatite toothpastes has proven to be a valuable prevention measure against dental caries in primary dentition since it prevents the risk of fluorosis.

생체모방 하이드록시아파타이트 치약은 치아불소증에 대한 위험을 방지하면서 영구치의 충치를 예방할 수 있음이 검증되었다.

KEYWORDS:

Biomimetic nanocrystals; Carbonate-hydroxyapatite; Enamel remineralization toothpaste; Zn-carbonate hydroxyapatite