J Contemp Dent Pract. 2018 Mar 1;19(3):306-312.

Comparison between Fluoride and Nano-hydroxyapatite in Remineralizing Initial Enamel Lesion: An in vitro Study. 불소바니쉬와 나노-하이드록시아파타이트의 초기 에나멜 리젼의 재광화 비교연구

Daas I¹, Badr S², Osman E³.

Author information

Division of Pediatric Dentistry,
Department of Developmental Sciences, Faculty of Dentistry, Beirut Arab
University, Beirut Lebanon, Phone: +962791959718, e-mail: i.n.daas77@gmail.com.

Division of Pediatric Dentistry,
Department of Developmental Sciences, Faculty of Dentistry, Beirut Arab
University, Beirut Lebanon; Department of Pediatric Dentistry and Public Health
Cairo University, Giza, Egypt.

Department of Restorative
Sciences, Faculty of Dentistry, Beirut Arab University, Beirut, Lebanon.

The aim
of this study was to compare the effectiveness of nano-hydroxyapatite (nano-HAP) paste and fluoride varnish in remineralizing initial enamel lesion in young permanent teeth and their ability to resist secondary caries under dynamic pH cycling quantitatively and qualitatively.

MATERIALS AND METHODS:

Initial caries-like lesions were artificially developed on 45 specimens. Specimens were divided into three groups: (1) Control (without treatment), (2) fluoride varnish (3M ESPE), and (3) nano-HAP paste (Desensibilize Nano P). The nano-HAP paste was applied twice separated by one pH cycle, and the varnish was applied only once followed by 7 days of pH cycling. All specimens were examined using DIAGNOdent® pen (KaVo, Germany), and a representative specimen was randomly selected from each group for qualitative evaluation using scanning electron microscope (SEM) at four stages: Baseline, after lesion formation, immediately after  emineralization, and after pH cycling. Data were statistically analyzed with Statistical Package for the Social Sciences (SPSS), version 20.

RESULT:

The degree of demineralization was significantly elevated in control group; however, no significant difference was found between fluoride varnish group and nano-HAP paste group (p < 0.001).

CONCLUSION:

Nano-HAP paste showed promising long-term protective effect in terms of surface depositions and maintaining a smooth surface compared with fluoride varnish.

나노 하이드록시아파타이트는 불소바니쉬에 비해 오랫동한 매끈한 치아표면과 치아표면 보호 효과를 보여주었다.

CLINICAL SIGNIFICANCE:

Based on the findings of this study, nano-HAP paste might be recommended as alternative remineralizing agent with lower fluoride concentration than fluoride varnish that could be beneficial for children, pregnant females, and those who are at high risk of dental fluorosis.

본 연구결과에 따르면, 나노 하이드록시 아파타이트 페이스트는 치아재광화촉진재로서 저농도불소바니쉬를 대체할 수 있다. 특히 치아불소증 고위험군 환자, 즉 아이들과 임산부에서 유용하다.

KEYWORDS:
Enamel lesion; Nano-hydroxyapatite Remineralization.