2019년 취학전 아동을 대상으로 한 불소 바니쉬의 충치예방효과에 관한 리뷰 및 메타분석 논문입니다.

Caries Res. 2019;53(5):502-513. doi: 10.1159/000499639. Epub 2019 Jun 20.

Fluoride Varnish and Dental Caries in Preschoolers: A Systematic Review and Meta-Analysis.

취학 전 아동에 대한 불소 바니쉬 도포와 충치예방: 체계적 리뷰와 메타분석

de Sousa FSO¹, Dos Santos APP², Nadanovsky P^3,4, Hujoel P^5,6, Cunha-Cruz J^5,7, de Oliveira BH¹.

Author information

1

Department of Community and Preventive Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.

2

Department of Community and Preventive Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil, ana.paulapires@uol.com.br.

3

Department of Epidemiology, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

4

Department of Epidemiology, Institute of Social Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil.

5

Department of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, Washington, USA.

6

Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.

7

Department of Health Services, School of Public Health, University of Washington, Seattle, Washington, USA.

Abstract

The aim of this study was to assess the effectiveness of fluoride varnish (FV) in reducing dentine caries at the patient, tooth, and surface levels as well as caries-related hospitalizations in preschoolers.

본 연구의 목적은 미취학 아동들에 대한 상아질 충치의 발생을 줄이는 불소 바니쉬의 효과성을 평가하기 위한 것이다.

We performed a systematic review of clinical trials of FV, alone or associated with an oral health program, compared with placebo, usual care, or no intervention. Bibliographical search included electronic searches of seven databases, registers of ongoing trials, and meeting abstracts, as well as hand searching. We performed random-effects meta-analyses and calculated confidence and prediction intervals. The search yielded 2,441 records; 20 trials were included in the review and 17 in at least one meta-analysis. Only one study had low risk of bias in all domains. We found no study reporting on caries-related hospitalizations. At the individual level, the pooled relative risk was 0.88 (95% confidence interval [CI] 0.81, 0.95); this means that in a population of preschool children with 50% caries incidence, we need to apply fluoride varnish in 17 children to avoid new caries in one child. At the tooth level, the pooled weighted mean difference was -0.30 (95% CI -0.69, 0.09) and at the surface level -0.77 (95% CI -1.23, -0.31). Considering the prediction intervals, none of the pooled estimates were statistically significant. We conclude that FV showed a modest and uncertain anticaries effect in preschoolers. Cost-effectiveness analyses are needed to assess whether FV should be adopted or abandoned by dental services.

취학전 아동을 대상으로 한 불소바니쉬 도포의 충치예방효과는 확실치 않다. 치과치료에서 불소 바니쉬를 폐기할지 채택할지에 대한 비용효과분석이 필요하다.

© 2019 S. Karger AG, Basel.

KEYWORDS:

Cariostatic agents; Dental caries; Meta-analysis; Preschool children; Topical fluorides