subject 불소와 나노 하이드록시아파타이트를 함께 사용한 상아세관봉쇄에 관한 연구
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date 19-06-14 14:50
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2018 Aug;81(8):843-854. doi: 10.1002/jemt.23046. Epub 2018 Apr 29.

Dentinal tubule occluding capability of nano-hydroxyapatite; The in-vitro evaluation.

나노하이드록시아파타이트의 상아세관봉쇄 능력

Abstract

In this in-vitro study, the effectiveness of experimental pure nano-hydroxyapatite (nHAP) and 1%, 2%, and 3% F¯ doped nano-HAp on dentine tubule occlusion was investigated. And also, the cytotoxicity of materials used in the experiment was evaluated. Nano-HAp types were synthesized by the precipitation method. Forty dentin specimens were randomly divided into five groups of; 1-no treatment (control), 2-specimens treated with 10% pure nano-HAp and 3, 4, 5 specimens treated with 1%, 2%, and 3% F- doped 10% nano-HAp, respectively. To evaluate the effectiveness of the materials used; pH, FTIR, and scanning electron microscopy evaluations were performed before and after degredation in simulated body fluid. To determine cytotoxicity of the materials, MTT assay was performed. Statistical evaluations were performed with F and t tests. All of the nano-HAp materials used in this study built up an effective covering layer on the dentin surfaces even with plugs in tubules. It was found that this layer had also a resistance to degradation. None of the evaluated nano-HAp types were have toxicity. Fluoride doping showed a positive effect on physical and chemical stability until a critical value of 1% F- . The all evaluated nano-HAp types may be effectively used in dentin hypersensitivity treatment. The formed nano-HAp layers were seem to resistant to hydrolic deletion. The pure and 1% F- doped nano-HAp showed the highest biocompatibility thus it was assessed that pure and 1% F- doped materials may be used as an active ingredient in dentin hypersensitivity agents.


나노하이드록시아파타이트에 1% F-이온을 첨가한 실험군이 가장 생체친화적이었으며 상아질지각과민처치제로서 사용 가능할 것으로 사료된다.​ 

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